The Spectrum of Pulmonary Histomorphology Changes in COVID-19 Cases
نویسندگان
چکیده
Abstract Introduction/Objective Pulmonary specimens following COVID-19 virus infection demonstrate a spectrum of pulmonary histomorphology. Six patients with history are summarized in this review. The purpose our study is to elucidate any possible correlations between clinical, laboratory, radiographic, and pathologic findings patients. Further, we aim characterize both non-specific specific histomorphology cytomorphology Methods/Case Report known lung biopsies/resections identified. A chart review performed collect clinical histories, the results PCR testing, radiographic impressions, interpretations histology, outcomes. Information tabulated. Results (if Case Study enter NA) most common, histological focal/diffuse acute injury, organizing or combination patterns. Unique features identified three cases, which illustrate viral cytopathic changes within hyperplastic pneumocytes. These include basophilic, vacuolated, granular cytoplasm variably sized cytoplasmic/nuclear inclusions. Virus-loaded pneumocytes typically phase, rarely injury phase. Immunohistochemical staining anti-nuclear capsule antibody appropriate controls shows focal positive one case. SARS-CoV-2 formalin-fixed paraffin-embedded (FFPE) tissue, while serum assay negative. Conclusion severity symptoms outcome unrelated degree involvement. Viral these associated phase either concurrent positivity immunohistochemical staining.
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2022
ISSN: ['0002-9173', '1943-7722']
DOI: https://doi.org/10.1093/ajcp/aqac126.323